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Millipore Sigma

MilliporeSigma

MilliporeSigma, a life science leader, is a business of Merck KGaA, Darmstadt, Germany.

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Explore the latest developments in Actives & Formulation

Welcome to our virtual exhibit. Learn about our game-changing innovations for drug discovery, drug development, and the manufacturing process from research to industrial scale. Explore our extensive digital library of resources and our on-demand webinars. Connect with one of our experts.

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Digital Library

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Effect of PEG Linkers on ADCs
Poster: Discover the importance of an appropriate linker and the need for thorough product characterization in order to understand the structure-function relationships of an ADC.
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Single-use Equipment Compatibility in ADCs
Application Note: Evaluate the physical compatibility and extractable results of a proposed single-use solution for conjugation, purification and sterile filtration for ADCs.
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Raw Materials for Small Molecule Drugs
White Paper: Explore best practices for ensuring a seamless transition of API raw material supply at critical junctions on the path from preclinical development to commercial manufacturing of small molecule drugs.
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Synthetic Lipids for Drug Development
White Paper: Discover the most important aspects to consider for lipid-based formulations, strategies in drug development of RNA therapeutics as well as raw material selection.
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Selecting the Optimal ODT Excipient System
White Paper: Explore factors to be considered when evaluating and selecting an ODT excipient system suitable for direct compression.
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Excipient Risk Assessment Guidelines
White Paper: Discover the relevant laws and guidelines, as well as voluntary standards developed by the industry to foster implementation.
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Enhancing Tablet Coating Formulation Development
Poster: Discover our formulation approach to individually adjust the film properties of the respective coating formulations by the addition of different plasticizers.
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Managing Protein Viscosity for Highly Concentrated Formulations
Poster: Explore our investigations on the effect of excipient combinations to manage protein viscosity.
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Webinar Library

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Single-use Manufacturing for ADCs Webinar
Learn more about Single Use (SU) processing for ADC GMP manufacturing. Explore our recommendations for consistent transfer of SU processes to manufacturing. Discover the pros and cons of SU for ADCs to understand if SU technology is right for your product. (44:31)
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Commercializing ADCs Webinar
Hear the story of a CMO preparing for the manufacture of a Commercial Antibody Drug Conjugate (ADC). Learn how to properly structure your development work, perform a thorough process risk assessment, prepare for pre-approval inspection. (53:37)
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Monodisperse aPEGs for ADCs Webinar
Learn more about the types of PEGs that are used in ADCs and find examples of successful implementation to change the biophysical properties of the construct. Explore why activated PEGs are widely used to improve the pharmacokinetics of drugs. (41:27)
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Continuous Manufacturing in Solid Dose Webinar
Learn more about the challenges of continuous manufacturing in solid dose, more accurately named “continuous tablet manufacturing”. Find out about the benefits, as well as critical parameters of this new technology and learn how to tackle the latter by choice of excipients. (50:26)
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Viscosity Reduction for Concentrated Protein Formulations Webinar
Discover our approach that combines different excipients to reduce viscosity of highly concentrated protein formulations and synergistic effects. Find out why an excipient portfolio approach is useful for reducing viscosity and how excipient combinations can be more efficient than the same concentration of a single excipient, e.g. the leading industry standard. (36:44)
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Lipid Based RNA Delivery and Vaccines Webinar
Learn more about the application of RNA therapeutics and the different drug delivery routes used in the clinic. Discover design principles for developing lipids-based RNA formulations and critical parameters to consider for cost effective development and consistent performance of RNA therapeutics and vaccines. (01:08:07)
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Polyvinyl Alcohol for Sustained Release Webinar
Discover how the gel-formation properties of PVA introduce sustained release and why compatibility with direct compression leads to simplified formulations. Explore how PVA can provide flexibility in sustained release formulation development. (57:49)
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New Requirements Concerning Nitrosamines Webinar
Learn more about the root causes that led to Nitrosamine contaminations in APIs and various potential sources for nitrosamine formation and/or introduction, approach for nitrosamine risk assessment for pharmaceutical starting materials. (1:06:56)
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Designing For Virtual Events – Friday, August 7th, 2020 – 7 pm to 8 pm
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Best Practices For Virtual Exhibiting – Saturday, August 8, 2020 – 7 pm to 8 pm
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